CentOS 6.1 x86_64 CD can be used only with 64bit PCs. CentOS 6.1 is a new version of the popular distribution built from source code for Red Hat Enterprise Linux 6.1. CentOS 6.1 is based on the upstream release EL 6.1 and includes packages from all variants. All upstream repositories have been combined into one, to make it easier for end users to work with. All machines running CentOS-Release-CR on 6.0 would already be running code that is included in the 6.1 install media. It is recommend everyone use the CR repository in order to get all bug-fix and security updates as soon as possible.
About CentOS
CentOS as a group is a community of open source contributors and users. Typical CentOS users are organisations and individuals that do not need strong commercial support in order to achieve successful operation. CentOS is 100% compatible rebuild of the Red Hat Enterprise Linux, in full compliance with Red Hat's redistribution requirements. CentOS is for people who need an enterprise class operating system stability without the cost of certification and support.